Prof Soo graduated from medical school at the University of Singapore with a distinction in biochemistry in 1975. He moved to Australia where he was trained as a Surgical Resident at Royal Adelaide Hospital, Bankstown Hospital and Prince of Wales Hospital, NSW. Surgical Registrar positions in a number of Surgery Departments in Australian hospitals between 1979 and 1983 led to the position of Senior Surgical Registrar/Lecturer in Surgery at the Royal Marsden Hospital and the Institute of Cancer Research in London from 1983 to 1985. Specialising in Head and Neck surgery, Prof Soo spent a further year at the Royal Marsden before continuing his training at the Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, USA.
He has trained international surgeons and has been well consulted as Visiting Professor in various medical facilities in many parts of the world.
Prof Soo has wide ranging research interests but has gained a particular reputation in the conduct of clinical trials for new cancer treatments and in the field of biophotonics and its role as a new imaging modality for the early detection of cancer.